Asked Questions

It is a sterile, injectable, non-pyrogenic, resorbable medical device based on cross-linked hyaluronic acid derived from bacterial fermentation.
FillZon® dermal gels are available in 5 versions specifically formulated for each aesthetic need.
FillZon® Fine: concentrated cross-linked hyaluronic acid.
FillZon® Lips: cross-linked hyaluronic acid at a medium concentration.
FillZon® Medium: cross-linked hyaluronic acid at a high concentration.
FillZon® Deep: extremely concentrated cross-linked hyaluronic acid.
FillZon® BBXL: concentrated cross-linked hyaluronic acid.

FillZon® works by increasing the volume of the dermo-epidermal tissue based on the natural ability of the hydrophilic molecules of hyaluronic acid to bind to an amount of water many times its weight. This allows the intradermal spaces to be filled and the intercellular matrix to be integrated, providing more turgidity to the tissues.
The cross-linking of the hyaluronic acid contained in the product makes the filling effect more stable and durable over time.

Only adults can undergo a treatment with FillZon®

FillZon® is intended for use as a temporary filler for the correction of skin defects such as wrinkles or scars. In addition to providing the skin with moisture thanks to the properties of hyaluronic acid.
It is also indicated in pathological conditions such as lipoatrophy related to HIV infection and antiretroviral therapy.
The following uses are specifically recommended:
FillZon® Fine to correct expression lines and fine-to-moderately pronounced superficial wrinkles. Specially indicated defects and areas: Marionette lines, smile lines, barcodes, periocular wrinkles and scars (acne, chickenpox).
FillZon® Lips is indicated for the correction of medium-surface wrinkles on the face. Defects and specially indicated areas: nasolabial wrinkles, nose, lips and glabellar lines.
FillZon® Medium is indicated to correct deep facial wrinkles and folds. Defects and specially indicated areas: nasolabial folds, marionette lines, temples, remodelling of facial contours and lips.
FillZon® Deep is indicated to correct very deep facial wrinkles and to restore facial volume. Defects and specially indicated areas: cheekbones, malar area, subzygomatic region, sub-malar region and chin.
FillZon® BBXL is indicated to correct more widespread skin imperfections, which affect large volumes and the body.

FillZon® should not be used: for injections into eyelids or bags under the eyes; for injections into blood vessels; for breast tissue augmentation; or for implants into bones, tendons, ligaments, or muscles.
FillZon® should not be given to patients with pre-existing or ongoing autoimmune diseases or those being treated with immunotherapeutic drugs; a proven tendency to develop hypertrophic or keloid scars, or pigmentation disorders; multiple severe allergies; infections and inflammatory processes in or near the area to be treated; coagulation disorders; recognised hypersensitivity to hyaluronic acid.
FillZon® should not be given to pregnant or nursing women, or to minors.
FillZon® is intended for subcutaneous or intradermal injection only; it should not be injected intravascularly.
Do Not use FillZon® in conjunction with other injectable products and do not mix it with other preparations before use.
Do not use FillZon® when the skin is red, swollen or pigmented.
Do not use FillZon® if you are running a fever or if you have an inflammatory or infectious condition.
Patients taking medication to slow down blood clotting may experience bruising or heavy bleeding at the injection site.
Patients undergoing anticoagulant treatment will be required to interrupt the administration of the product, in accordance with their physician's instructions, at least 14 days prior to the administration of FillZon® injections.
It is recommended that FillZon® should not be used in areas where other implants have been performed or at the same time as other injectable products.

There is a recognised incompatibility between hyaluronic acid and quaternary ammonium salts such as benzalkonium chloride. Therefore, avoid bringing FillZon® into contact with such substances or using medical-surgical material containing quaternary ammonium salts.
What recommendations should the medical professional give to the patient?
Before commencing treatment with this device, the physician must inform the patient as to its composition and characteristics, warnings and precautions for use, contraindications, and possible adverse reactions.
The doctor should advise the patient not to apply any make-up for 24 hours after the injection and inform him or her that, during the period of remission, that is, until the swelling or redness has completely disappeared, they should avoid exposing the treated area to direct sunlight, UV lamps or the cold.
If a laser treatment, chemical peel or dermabrasion is performed after using FillZon®, the patient may experience an inflammatory reaction. For the same reason, FillZon® can only be used when reactions to any previous treatment have ceased completely.
After use, syringes and needles can represent a potential biological hazard. They should be handled with care and disposed of in accordance with approved medical practices.

Before commencing treatment, the doctor should inform the patient that there are possible side effects related to any intradermal application, which may occur immediately or after a period of time.
Certain injection-related adverse reactions can occur after using FillZon®, including pain, itchiness, alterations in pigmentation and tissue density in the area around the injection site. Generally speaking, these usually resolve themselves spontaneously within a week.
Sometimes, small oedemas can appear that are reabsorbed in a few days.
Hardening or the appearance of nodules at the injection site; in very rare cases, significant granulomas or inflammatory reactions, hives, necrosis and urticaria, which can appear even after 2-4 weeks.

Before commencing treatment with this device, the physician must inform the patient as to its composition and characteristics, warnings and precautions for use, contraindications, and possible adverse reactions.
In addition, the doctor must first obtain a medical history and an assessment of any previous immunological or allergic problems the patient may have had and determine compatibility with the use of FillZon®.
Finally, the physician must evaluate the skin areas involved in the treatment to determine whether the patient is a suitable candidate for the application and the effective utility of the treatment. FillZon® may only be administered by qualified medical personnel.
To obtain a correct final result of the treatment, it is essential to use a correct injection technique.
Before injection, disinfect the area to be treated with alcohol or another antiseptic solution.
The product must be injected using a sterile syringe with a fine needle.
For FillZon® Fine we recommend a 30G needle, for FillZon® Lips a 27G or 30G needle, for FillZon® Medium a 27G or 25G needle, for FillZon® Deep a 25G needle, for FillZon® BBXL an 18G cannula.
However, the choice of the appropriate needle and method of injection is at the discretion of the physician.

The amount of product to be injected is determined by the depth of the wrinkle or skin lesion and the dose can be easily measured using graduated syringes.
Before performing the procedure, the symmetry of the areas of the face to be treated must be carefully evaluated, scheduling an injection on the right and left side with the same amount of material and in points that coincide in symmetry.
Immediately before applying the injection, take the syringe out of the protective vial, remove the cap of the syringe and attach the needle by screwing its cone to the Luer-Lock system of the syringe until you feel resistance.
To ensure a safe use of FillZon®, it is important to use a suitable needle and to insert it correctly into the syringe, as incorrect insertion could lead to the needle becoming detached from the syringe during the injection procedure.
Remove the needle protection cap only when you are ready to perform the injection. Do not use unsterile, bent, deformed, or not fully intact needles.
Before performing the injection, expel the air from the syringe until a drop of product emerges from the tip of the needle. Insert the needle into the skin at an angle of 30 degrees, following exactly the course of the wrinkle or depression and injecting the product into the mid dermis.
If the hyaluronic acid is introduced too deeply, the final effect will last for a shorter period of time; on the other hand, if it is injected too superficially, nodules and granulomas may form.
Never exert excessive pressure on the syringe; inject FillZon® while slowly withdrawing the needle, depositing an even amount of product over the entire chosen area. Stop pressing the plunger of the syringe before you withdraw the needle from the skin, in order to avoid spilling material from the injection site. If swelling appears immediately, cold compresses should be applied briefly. Note: The graduation on the syringe has no measuring function but is provided only as a visual check of the injected material.
Immediately after performing the injections, apply firm pressure to and massage the treated area to ensure an even distribution of the product.

A package of FillZon® contains: a syringe pre-filled with the product, graduated to 1 ml, for FillZon® Fine, FillZon® Lips, FillZon® Medium, FillZon® Deep, and with a graduation of 10 ml for FillZon BBXL.
The syringe is supplied with a Luer-Lock system inside a vial with an adhesive label. In addition, it contains a set of two adhesive labels with the batch number and the expiry date, one of which must be attached to the patient’s medical record while the other should be given to the patient him or herself.
These procedures must be carried out in order to guarantee the traceability of the product.
Please read the instructions for use carefully before using the device.
Two 30G needles for FillZon® Fine, two 27G needles for FillZon® Lips and FillZon® Medium, and two 25G needles for FillZon® Deep.

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